Objective To study the protective effect of Qingxuan Jiangya Decoction（Decoction for treating dizziness and lowering blood pressure） on blood pressure and kidney of spontaneous hypertension rats（SHR）.Methods Forty SHR were randomized into 4 groups

i.e.Qingxuan Jiangya Decoction high-dose group and low-dose group

accepted Qingxuan Jiangya Decoction 5.372g/d and 1.7g/d respectively

the telmisartan group

accepted telmisartan 2.4mg/d

and the model group

with 10 rats in each.Ten Wistar rats w ere taken into normal control group.The rats were treated with intragastric administration for 8 weeks in succession.Blood pressure was determined respectively before treatment

2h

6h

12h

24h after first treatment and 3d

1 week

4 weeks and 8 weeks treatment.After the last blood pressure examination

10% chloral hydrate anesthesia was adopted to collect blood for enzyme linked i mmunosorbent assay（ELISA） and radioimmunoassay（RIA） tests to measure the Ang Ⅱ and Ang1-7 contents.HE staining was used to observe the pathological chan ges of kidney tissue

and the immunohistochemical method was applied to determine the AngⅡ expre ssion in the kidney.Results With the first time intragastric administration

blood pressure in the high-dose and low-dose of Qingxuan Jiangya Decoction was not signi ficantly changed

while the systolic and diastolic pressure of the telmisartan group was signi ficantly lowered（P<0.05） 2 hours after treatment.After the treatment for 8 weeks in succession

blood pressure in the high-dose and low-dose Qingxuan Jiangya Decoction groups was not significantly changed（P>0.05）

the systolic pressure of the telmisartan group was significantly lowered（P<0.05）

and the systolic pressure of the model group was increased significantly（P<0.05 or P<0.01）.Ang Ⅱ and Ang1-7 contents in the SHRs were low er than in the normal rats（P<0.05）;and the glomerular and tubular hyperplasia in all treatment groups were both significantly inhibited compared with those of the model group.C onclusion Qingxuan Jiangya Decoction is effective in controlling the further increase of SHR s ystolic pressure

inhibitying the hypertensive glomerular and tubular hyperplasia

thus providing a potential kidney protection for SHR.