Objective To observe the therapeutic effect of Qingzao Yangyin Decoction（Decoction for Dryness-Clearing and Yin-Nourishing）for infants with hand foot and mouth disease（HFMD）in Xinjiang Uygur Autonomous Region and to study the effect on houmoral immunity of the patients.Methods Totally 80HFMD patients were randomized into treatment group and control group

with 40in each.The treatment group accepted Qingzao Yangyin Decoction（Decoction for Dryness-Clearing and Yin-Nourishing）once daily

while the control group received acyclovir tablet 20mg/kg each time

four times a day.The treatment course lasted for 5days.The recovery rate and total effective rate of two groups were compared.The immunoglobu-lin and complement levels were detected before and after treatment.Results The recovery rate of the treatment group and con-trol group was 72.5%and 40.0%respectively

the difference between was statistically significant（P<0.01）.The total effect rate of the treatment group and control group was 92.5%and 70.0%respectively

the difference between was statistically sig-nificant（P<0.05）.The levels of immunoglobulin G and immunoglobulin M were significantly decreased in both groups after the treatment（P<0.01）

and the difference between groups was statistically significant（P<0.05or P<0.01）.The level of immunoglobulin A was significantly increased in both groups after the treatment（P<0.01）

but the difference between groups was not statistically significant（P>0.05）.The differences of complement 3and complement 4levels were not statistically sig-nificant whether in or between the two groups（P>0.05）.Conclusion Dryness-Clearing and Yin-Nourishing Decoction is ef-fective for HFMD in Xinjiang

and could improve the immune function.