Objective To observe the therapeutic effect and safety of Wufu Xinnaoqing Soft Capsule（capsule for cardiovascular and cerebral vascular disease）for Alzheimer’s disease（AD）of qi stagnation and blood stasis syndrome.Methods Eighty AD patients of qi stagnation and blood stasis syndrome were randomized into control group of 39cases and treatment group of 41cases.The Aricept tablet was given to both groups 5to 10mg per time

once daily.Wufu Xinnaoqing soft capsule was added to the treatment group with 0.8g per time

three times daily.The treatment lasted for 6months.The clinical effect was observed through Mini-Mental State Examination（MMSE）

Alzheimer’s Disease Assessment Scale-Cognitive Subscale（ADASCog）

Activity of Daily Living Scale（ADL）

scores of Chinese medical symptoms and electroencephalogram（EEG）before and after the treatment.The adverse action was observed as well.Results After the treatment

the scores of MMSE were significantly increased

while the scores of ADAS-Cog

ADL and Chinese medical symptoms decreased in both groups（P<0.05or P<0.01）

especially in the treatment group（P<0.01）.After the treatment

the EEG wave frequency ofαandθwas significantly increased and the wave amplitude was increased as well in both groups（P<0.05or P<0.01）

while the amplitude ofθ decreased（P<0.01）.The change ofαfrequency

αamplitude andθamplitude in the treatment group was superior to those of the control group（P<0.05or P<0.01）.There was no significant difference in blood routine

urine routine

stool routine

liver function

renal function and cardiogram after the treatment in both groups（P>0.05）.Conclusion Wufu Xinnaoqing soft capsule is effective for Alzheimer’s disease（AD）of qi stagnation and blood stasis syndrome with few side effects.