Objective To evaluate the effect of Dafengzi Ointment[Ointment of hydnocarpus（Hydnocarpi Semen）] on atopic dermatitis（AD）.Methods Sixty AD patients were randomized into treatment group and control group

with 30 in each.Both groups were given modified decoction based on Kangmin Yihao Formula（No.1 Formula for antianaphylaxis）.Dafengzi Ointment and Tacrolimus Ointment was applied in the treatment group and control group respectively

twice daily

in the morning and evening.The daily dosages of both ointments were within 10g.Four 4 weeks as a treatment course

and the treatment lasted for 2 courses.The therapeutic effect was evaluated through observing the clinical symptom scores and the main single symptom.Results The total effective rate of the treatment and control group was 93.33% and 96.67% respectively.The difference in the clinical effect between groups was not statistically significant（P>0.05）.Both groups were significantly effective in scoring atopic dermatitis（SCORAD）

skin lesions

sleep quality and pruritus（P<0.05）.Comparing with in-group

the differences between the first treatment course and second treatment course were statistically significant in both groups（P<0.05）.Comparing with the same timing

there was no significant difference between groups in SCORAD and skin lesions（P>0.05）.Comparing with the control group

the treatment group could significantly improve sleep quality

relieve pruritus

asteatosis and excoriation（P<0.05）.There was no significant difference between groups in relieving papule

edema

exudation

incrustation and lichenification（P>0.05）.Conclusion Dafengzi Ointment is effective for AD with fine clinical application.