Objective To study the therapeutic effect of Buqin Tablet [Tablet of Baibu（Radix Stemonae） and Huangqin（Radix Scutellariae）] for multidrug-resistant tuberculosis（MDR-TB） and its mechanism.Methods Fifty-two cases of MDR-TB were randomized into treatment group（17 cases）

Vaccae group（17 case） and control group（18 cases）.All groups were given anti-tuberculosis drugs.Buqin Tablet and Vaccae injection was added respectively in the treatment group and Vaccae group.The treatment lasted for 6 months.The therapeutic effect was observed and the contents of interleukin-12（IL-12） and interferon-α（IFN-α） were detected before and after 2 months and 6 months of treatment.Results After 2 months

the effective rate of the treatment group

Vaccae group and control group was 82.35%（14/17）

52.94%（9/17） and 41.18%（7/17） respectively.The effective rate of the treatment group was superior to that of control group（P<0.05）.There was no significant difference between the Vaccae group and control group（P>0.05）.After 6 months

the effective rate of the treatment group

Vaccae group and control group was 88.24%（15/17）

82.35%（14/17） and 70.59%（12/17） respectively.Comparing with the control group

the effective rates of the treatment group and Vaccae group increased significantly（P<0.05）.The effective rates of the control group and Vaccae group increased significantly after 6 months of treatment as compared with those after 2 months of treatment（P<0.05）.There was no significant difference in the treatment group between different treatment times（P>0.05）.After 2 months

the contents of IL-12 and IFN-α increased in the treatment group and Vaccae group without statistical significance（P>0.05）.After 6 months

the contents of IL-12 in all the groups increased significantly

especially in the treatment group and Vaccae group（P<0.01）.The contents of IFN-α increased significantly in all the groups（P<0.05）.Comparing with the control group

the contents of IL-12 and IFN-α increased in the treatment group and Vaccae group after 2 months of treatment

especially after 6 months of treatment（P<0.05 or P<0.01）.Comparing with the treatment group

the contents of IL-12 and IFN-α increased in the Vaccae group both after 2 months and 6 months of treatment without statistical significance（P>0.05）.Conclusion Buqin Tablet is effective for MDR-TB by increasing the contents of IL-12 and IFN-α.