Objective To observe the therapeutic effect and mecha nism of Jianpi Huazhuo Formula（decoction for strengthening the spleen and resolving the turbid） for impaired glucose regulation（IGR）.Methods Ninety cases of IGR were randomi zed into 3 groups.The basic treatment group was given diet and exercise interve ntion.Pioglitazone and Jianpi Huazhuo Decoction was added respectively to the w estern medication group and Chinese medication group.The treatment course laste d for 12 weeks.The levels of body mass index（BMI）

serum adiponectin

fasting blood glucose（FBG）

postprandial 2 hours blood glucose（2hBG）

fasting insulin（FINS）

postprandial 2 hou rs insulin（2hINS） and glycated hemoglobin A1c（HbA1c） were observed.Res ults After treat ment

the level of 2hBG was significantly decreased in the basic treatment group（P<0.05 or P<0.01）.The levels of BMI

FBG

2hBG

HbA1c

FINS and 2hINS were significantly decreased in the western medication group and Chinese medication group（P< 0.05）

but the level of serum adiponectin increased significantly（P<0.01）.Com parin g with the basic group

the index mentioned above obviously improved in the west ern medication group and Chinese medication group（P<0.05）.There was no si gnificant difference between the western medication group and Chinese medication grou p（P>0.05）.Conclusion Jianpi Huazhuo Formula co uld regulate the level of bloo d glucose

which maybe relevant to elevating the level of serum adiponectin

inc reasing insulin sensitivity and improving insulin resistance