Objective To investigate the quality of life（QOL） in human immunodefic iency virus/acquired immune deficiency syndrome（HIV/AIDS） patients and the acce ptance of Chinese version of WHOQOL-HIV by qualitative interview in order to pr ovide evidence for further modification.Methods The semi-struct ured and one-on-o ne interview was conducted after the interview outline was designed.The intervi ew was recorded and transcribed into text for theme analysis.Results Nineteen participants were interviewed

9 of them were doctors and nurses

10 were HIV/AIDS patients.Both populations showed roughly the same understanding in the relation among QOL with physiol ogical condition

psychological state

social connection

discrimination

family

treatment

work and economic status in HIV/AIDS patients.On the acceptance of WHOQOL-HIV

both populations considered it was simple and easy to understand a lthough they had different point of view.Conclusion Qualitative interview could get the characters of QOL effectively and provide direct evidence for modifying WHOQOL-HIV.