Objective To observe the effect of Shexiang Baoxin Pi ll [pill of Shexiang（Moschus） to protect heart] on hemodynamics and inflammatory factor in rats w ith acute myocardial infarction（AMI） and its mechanism of improving ventricular remodeling.Methods Seventy SD rats were selected

among which 8 rats were set as blank control group

and the others were made AMI models by ligating the left anterior d esecending coronary arteries.Fourty-four successfully made models were randomized into the sham operation group（n=8）

AMI model group（n=9）

Shexiang Baoxin Pill equal-dose group（n=9）

Shexiang Baoxin large-dose group（n=9） and simvastatin group（n=9）.The blank control group

sham operation group and AMI model group were administered normal saline simvastatin group was given simvastatin tablet 0.2mg/100g by gastric perfusion

and Shexiang Baoxin Pill 1.4mg/100g or 2.4mg/100g was given to Shexiang Baoxin Pill equal-dose group and large-dose group respectively by gastric perfusion.Two weeks later

the hemodynamic parameters

inter leukin-6（IL-6） and tumor necrosis factor-α（TNF-α） were detected.Res ults Compa ring with the blank control group

the left ventricular end-systolic pressure（L VESP）

LV+dp/dtmax and LV-dp/dtmax decreased significantly in the AMI model gro u p（P<0.01）

while left ventricular end-diastolic pressure（LVEDP） and the conten t of IL-6 and TNF-α increased significantly（P<0.01）.Comparing with the AMI mo del group

LVESP

LV+dp/dtmax and LV-dp/dtmax in the Shexiang Baoxin Pill groups increased significantly（P<0.05 or P<0.01）

while LVEDP and the conten t of IL-6 and TNF-α decreased significantly（P<0.05 or P<0.01）.Conclus ion Shexiang Baoxi n Pill could improve the hemodynamic parameters and reduce the release of inflam matory factors for AMI model rats

which maybe the mechanism of improving ventri cular remodeling after AMI.