Objective To observe the therapeutic effect of knee k neading-patella pu shing-acupoint pressing combined with glucosamine hydrochloride capsules for kn e e osteoarthritis with blood stasis syndrome.Methods Totally 180 cases（248 knee s） were randomized into treatment group（90 cases

125 knees） and the contro l group（90 cases

123 knees）.Both groups were given glucosamine hydrochloride capsules

while votalin emulgel and manipulation was added in the control group and the treatment group respectively.The therapeutic effect was evaluated by co mparing the scores of knee movement function and the Western Ontario and McMaste r Universities Arthritis Index（WOMAC） osteoarthritis index before and after tre atment.Results The treatment was conducted completely to 79 cas es（111 knees） in the treatment group with 11 cases（14 knees） lost and 76 cases（103 knees） in the control group with 14 cases（20 knees） lost respectively.There was no significant difference bet ween groups in expulsion rate（P>0.05）.After treatment

the scores of knee move ment function were significantly increased and WOMAC index were significantly de creased in both groups（P<0.01）.Comparing with the same stage in the contr ol gr oup

the increase of knee movement function scores and decrease of WOMAC index w ere significantly higher in stage I and Ⅱ in the treatment group（P<0.05 o r P<0.01）.The excellence rates of the treatment in stage I and Ⅱ were significantly higher than those of the control group（P<0.05）.The difference in effective rate between groups was not statistically significant（P>0.05）.Conclusio n The manipu lation of knee kneading-patella pushing-acupoint pressing could effectively re li eve the symptoms and improve the joint function

especially for knee osteoarthri tis patients in stageⅠ and Ⅱ.