Objective To analyze the relation between peripheral blood T lymphocyte subsets and Chinese medicine syndrome in human immunodeficiency virus/acquired immune deficiency syndrome（HIV/AIDS） patients.Methods Totally 113 HIV/AIDS patients were investigated and followed up for 12 months.Man-machine system was used to identify the syndromes according to the diagnostic materials.CD4+ counts and CD8+ counts were monitored.The relation between peripheral blood T lymphocyte subsets and Chinese medicine syndrome was analyzed.Results At the beginning

the top four Chinese medicine syndromes were liver depression and qi stagnation syndrome

qi-yin deficiency syndrome

spleen qi deficiency syndrome and liver-stomach disharmony syndrome.After 12 months of follow-up

the top four Chinese medicine syndromes were liver depression and qi stagnation syndrome

qi-yin deficiency syndrome

spleen qi deficiency syndrome and spleen-kidney yang deficiency syndrome.At the beginning

CD4+ and CD8+ counts in liver-stomach disharmony syndrome were significantly higher than those in spleen qi deficiency syndrome and qi-yin deficiency syndrome（P<0.05 or P<0.01）

and CD8+ counts in liver depression and qi stagnation syndrome were significantly higher than that in spleen qi deficiency syndrome（P<0.01）.After 12 months of follow-up

there was no significant difference between syndromes in CD4+ and CD8+ counts（P>0.05）.There was no significant difference in immune reconstitution of CD4+ of all syndromes before and after highly active antiretroviral treatment（P>0.05）.There was statistical significance in correlation coefficient of initial CD8+ counts stratification and immunological response 12 months later（r=0.384

P<0.001）.Conclusion The CD4+ and CD8+ counts in peripheral blood T lymphocyte subsets are closely related to Chinese medicine syndrome in AIDS patients.