化痰利湿活血方加减治疗非酒精性脂肪性肝炎患者96例临床观察

赵文霞; 刘全忠; 刘君颖; 冀爱英; 马素平

doi:10.13288/j.11-2166/r.2012.12.002

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化痰利湿活血方加减治疗非酒精性脂肪性肝炎患者96例临床观察

临床研究 | 更新时间：2021-11-17

- 化痰利湿活血方加减治疗非酒精性脂肪性肝炎患者96例临床观察
- Clinical Observation of Huatan Lishi Houxue Formula for 96 Patients with Non-Alcoholic Steatohepatitis
- 中医杂志 2012年53卷第12期页码：1025-1027
- 作者机构：
  
  1. 南京中医药大学
  2. 河南中医学院第一附属医院消化科
- 作者简介：
- 基金信息：
  
  “十一五”国家科技支撑计划资助项目（2007BAI20B095）
- DOI：10.13288/j.11-2166/r.2012.12.002
  中图分类号： R259
- 纸质出版：2012
- 稿件说明：
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[1]赵文霞,刘全忠,刘君颖,冀爱英,马素平.化痰利湿活血方加减治疗非酒精性脂肪性肝炎患者96例临床观察[J].中医杂志,2012,53(12):1025-1027.

ZHAO Wenxia1, LIU Quanzhong2, LIU Junying2, et al. Clinical Observation of Huatan Lishi Houxue Formula for 96 Patients with Non-Alcoholic Steatohepatitis[J]. Journal of Traditional Chinese Medicine2012, 53(12): 1025-1027.
[1]赵文霞,刘全忠,刘君颖,冀爱英,马素平.化痰利湿活血方加减治疗非酒精性脂肪性肝炎患者96例临床观察[J].中医杂志,2012,53(12):1025-1027. DOI： 10.13288/j.11-2166/r.2012.12.002.

ZHAO Wenxia1, LIU Quanzhong2, LIU Junying2, et al. Clinical Observation of Huatan Lishi Houxue Formula for 96 Patients with Non-Alcoholic Steatohepatitis[J]. Journal of Traditional Chinese Medicine2012, 53(12): 1025-1027. DOI： 10.13288/j.11-2166/r.2012.12.002.

摘要

目的观察化痰利湿活血方加减对非酒精性脂肪性肝炎（NASH）患者丙氨酸氨基转移酶（ALT）、肝/脾CT值的影响。方法共收集4个中心的NASH患者194例

随机分为治疗组96例和对照组98例

治疗组给予基本方化痰利湿活血方颗粒剂加兼证方颗粒剂

每日1剂。对照组给予多烯磷脂酰胆碱（易善复）胶囊

每次456mg

每日3次

两组均连续治疗3个月。观察两组患者治疗前及治疗90天、180天ALT水平、肝/脾CT值的变化。结果两组治疗90天、180天ALT水平均明显低于本组治疗前

肝/脾CT值明显高于本组治疗前（P<0.05）。治疗第90天、180天治疗组ALT水平明显低于对照组

肝/脾CT值明显高于对照组（P<0.05）。结论化痰利湿活血方加减可降低NASH患者ALT水平及提高肝/脾CT值

从而达到治疗NASH的目的。

Abstract

Objective To observe the effect of Huatan Lishi Huoxue Formula（formula to transform phlegm

disinhibit dampness and quicken the blood） on alanine aminotransferase（ALT） and the ratio of the liver and the spleen CT values in patients with non-alcoholic steatohepatitis（NASH）.Methods Totally 202 NASH patients from 4 centers were randomized into treatment group of 96 cases and the control group of 98 cases.The treatment group was given modified Huatan Lishi Huoxue Formula

one dosage daily.The control group was given polyene phosphatidylcholine（Essentiale） capsule

456mg each time

three times daily.The treatment course lasted for 3 months.The levels of ALT and the ratios of the liver and the spleen CT values were observed pretreatment and on the 90th and 180th day of the treatment.Results The levels of ALT were significantly decreased and the ratios of the liver and the spleen CT values were significantly increased in both groups after 90 and 180 days of treatment（P<0.05）

especially in the treatment group（P<0.05）.Conclusion Huatan Lishi Huoxue Formula is effective for NASH.It could significantly decrease the level of ALT and increase the ratio of the liver and the spleen CT values.

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