Objective To select the effective formulas for rheumatoid arthritis（RA） with anemia.Methods Sixty RA patients with anemia were randomized into the treatment group and control group

with 30 in each.The treatment group was given Duhuo Jisheng Decoction（Pubescent Angelica and Mistletoe Decoction） combined with leflunomide and methopterin.The control group was given Guipi Decoction（Spleen-Returning Decoction） and the same chemotherapy as the treatment group.One treatment course lasted for 4 weeks in both groups.After 3 courses of treatment

rest pain

time of morning stiffness

grasp force

tender joint count（TJC）

swollen joint count（SJC）

evaluation by patients or doctors

symptoms of TCM

blood routine

rheumatoid factor（RF）

erythrocyte sedimentation rate（ESR）

C-reaction protein（CRP）

liver function

renal function

urine routine and adverse effect were observed.Results There were one case of cure

13 cases of excellence

7 cases of validity and 9 cases of invalidity in the control group

with a total effective rate of 70.0%.There were 4 cases of cure

16 cases of excellence

7 cases of validity and 3 cases of invalidity in the treatment group

with a total effective rate of 90.0%.The difference in the total effective rate was statistically significant between groups（P<0.05）.After treatment

the differences in rest pain

time of morning stiffness

grasp force

TJC

SJC and the evaluation by patients or doctors were statistically significant both between groups and in group（P<0.05）.The content of hemoglobin increased and the levels of platelet

RF

ESR and CRP decreased significantly in both groups（P<0.05）

especially in the treatment group（P<0.05）.Symptoms of anemia were significantly relieved in both groups（P<0.05）

especially in the treatment group（P<0.05）.The quality of life significantly improved in both groups（P<0.05）

especially in the treatment group（P<0.05）.26 cases（86.7%） and 20 cases（66.7%） were improved by 50% improvement of American College of Rheumatology（ACR） outcome measures in the treatment group and control group respectively

with a significant difference between groups（P<0.05）.Conclusion Duhuo Jisheng Decoction is more effective than Guipi Decoction for RA with anemia.