Objective To observe the therapeutic effect of Modified Spleen-fortifying Qi-boosting Phlegm-transforming Formula on lung cancer related fatigue with Cancer Fatigue Scale（CFS）.Methods Sixty three cases of lung cancer were randomized into Chinese medication intervention group of 32cases and blank control group of 31cases.Both groups were given chemotherapy.The Chinese medication group was given Modified Spleen-fortifying Qi-boosting Phlegm-transforming Formula from the 1st day of the chemotherapy for 2weeks.The dimensions of CFS

total score and the absolute counts of red blood cells（RBC）

hemoglobin

white blood cells（WBC）and neutrophils were observed before and after chemotherapy.Results The dimensions of CFS and total scores significantly decreased on the 14th day of chemotherapy as compared with before chemotherapy and the 3rd day of chemotherapy（P<0.05or P<0.01）in the Chinese Medication group.The emotion dimension

body dimension and total score significantly increased in the blank control group as compared with before chemotherapy

but significantly decreased as compared with the 3rd day of chemotherapy（P<0.05or P<0.01）.On the 14th day of chemotherapy

the dimensions of CFS and total score in the Chinese medication group were lower than those in the blank control group（P< 0.05）.RBC and hemoglobin decreased on the 14th day of chemotherapy in both groups and on the 3rd day of chemotherapy in the blank control group（P<0.05）.There was no significant difference between before and after chemotherapy in the absolute counts of WBC and neutrophils in both groups（P>0.05）.There was no significant difference between groups in various physical and chemical indicators at each time point（P>0.05）.Conclusion Modified Spleen-fortifying Qi-boosting Phlegm-transforming Formula for lung cancer could relieve fatigue in lung cancer patients undertaking chemotherapy and reduce the side effects of chemotherapy.