Objective To investigate the hemodynamic changes in intracerebral hemorrhage（ICH） patients and observe the effect of Didang Pill（Dead-On Pill） on perihematoma perfusion and prognosis in ICH patients.Methods Sixty ICH patients were randomized into group I（conventional treatment） and group II（conventional treatment combined with Didang Pill）

with 30 in each.The treatment course lasted for 28 days.The relative cerebralbolood flow（rCBF）

relative cerebralblood volume（rCBV）

mean transit time（MTT）

and time-to-peak（TTP） were detected by computed tomography（CT） perfusion before treatment and on the 7th

14th and 28th day of treatment.The Institutes of Health Stroke Scale（NIHSS）

Barthel Index（BI） and Chinese medical symptoms were assessed.Results The rCBF and rCBV in both groups were the lowest on the 7th day of treatment and then increased gradually.MTT and TTP reached a peak on the 7th day of treatment and then reduced gradually.The rCBF and rCBV in group II were significantly higher than those in group I on the 14th and 28th day of treatment（P<0.05 or P<0.01）.The MTT and TTP in group II were significantly lower than those in group I on the 14th and 28th day of treatment（P<0.05 or P<0.01）.The NIHSS scores in group II were significantly lower than those in group I on the 14th and 28th day of treatment（P<0.05 or P<0.01）.The BI scores in group II were significantly higher than those in group I on the 28th day of treatment（P<0.05 or P<0.01）.The scores of Chinese medical symptoms in group II were significantly lower than those in group I on the 14th and 28th day of treatment（P<0.05）.Conclusion There exists persistent hypoperfusion in the perihematoma after ICH.Hypoperfusion is fluctuated with time.Didang Pill could obviously promote the perihematoma perfusion after ICH

improve the nerve function and relieve Chinese medical symptoms.