ObjectiveTo observe the effect of Modified Simiao Po wder on the inflam matory factors in impaired glucose tolerance（IGT） patients with syndrome of dam p-heat encumbering the spleen.MethodsSixty-seven IG T patients were randomized into treatment group（35 cases） and the control group（32 cases）.The contro l group was given diet and exercise guidance.Modified Simiao Powder was added i n the treatment group.The treatment lasted for one month.The changes of the cl inical symptoms

fasting blood glucose（FBG）

2-hour postprandial blood glucose （2h-PBG）

fasting insulin（FINS）

interleukin-6（IL-6）

adiponectin（ADP）

bo dy mass index（BMI） and insulin activity index（IAI） were compared before and after treatment.ResultsThe scores of TCM symptoms were imp roved in both groups（P<0. 05）.The levels of BMI

FINS and IL-6 were significantly decreased while ADP i n creased in the treatment group（P<0.05）.Comparing with the control group

Modif ied Simiao Powder could significantly improve the scores of TCM symptom

decreas e the levels of FBG

FINS and IL-6 and increase the levels of ADP and IAI（P <0.0 5）.ConclusionModified Simiao Powder can improve the i nsulin resistance of IGT patients by modulating the inflammatory factors.