ObjectiveTo observe the feasibility and advantage of insulin glargine （IG） and nateglinide combined with Chinese medication for elderly patients with type 2 diabetes mellitus（T2DM）.MethodsSixty elderly patients with T2DM were r andomized into treatment group and control group

with 30 in each.The c ontrol group was given subcutaneous injection of IG before bedtime and oral admi nistration of nateglinide before meals.The treatment group was given fund amental formulas according to different TCM syndromes of yin deficiency exuberan t heat

qi-yin dual deficiency and yin-yang dual deficiency on the basis of th er apy in the control group.The treatment lasted for 6 months.The glycemic contro l

level of C peptide

TCM syndrome scores and q uality of life（QOL） scores were observed.ResultsThe scores of TCM syndrome we re significantly improved in the treatment group after treatment（P<0.01）

with significant differences with the control group after treatment（P<0.05 o r P<0.01）.After 3 and 6 months of treatment

the QOL scores improved significantly in the treatment group（P<0.05）

with significant difference as compared with the control grou p（P<0.05）.After treatment

there was no significant difference between gr oups in fasting blood glucose（FBG） and level of C peptide（P>0.05）.The differences between groups in daily dosage of insulin and hypoglycemia were statistically significant（P<0.05）. ConclusionGlargine insulin and nateglinide combined w ith Chinese medication is effe ctive in controlling blood sugar and improving quality of life for elderly patie nts with T2DM

with a better efficacy and safety as compared with single western medication.