Objective To observe the effect of combination therapy of Chinese medicine on the quality of life（QOL） and mental state in community-based rehabilitation for stroke patients.Methods Totally 327 patients were randomized into observation group of 176 cases and control group of 151 cases.Both groups were given community-based rehabilitation.The observation group was added with the combination therapy of Chinese medicine such as Chinese patent medicine and acupuncture.The improvement of QOL was assessed by functional comprehensive assessment（FCA） and the mental state was assessed by Hamilton Self-Rating Anxiety Scale（SAS） and Self-Rating Depression Scale（SDS） before treatment and as compared with 3 or 6 months after treatment.Results The FCA scores were significantly increased in both groups 3 and 6 months after treatment（P<0.05）.After 6 months

the FCA score was significantly increased in the observation group

with statistical difference as compared with that after 3 months（P<0.05）.Difference between groups after 3 and 6 months was significant（P<0.05）.The scores of SAS and SDS were significantly improved in both groups 3 and 6 months after treatment（P<0.05）

especially in the observation group（P<0.05）.The difference in SAS and SDS score between groups after 3 and 6 months was also significant（P<0.05）.Conclusion The combination therapy of Chinese medicine could improve QOL and mental state of the community-based rehabilitation of stroke patients.Its efficacy is superior to that of simple rehabilitation therapy.