Objective To explore the effect and mechanism of Naoluo Xintong Liquid（liquid to free the network vessels of the brain and the heart）on the coagulation and fibrinolytic system in rats with focal cerebral ischemia.Methods Forty Wistar rats were selected and 10rats were divided into normal group

other 30were treated to make middle cerebral artery occlusion models with suture method.The models were randomized into three groups

i.e.model group

Naoluo Xintong group and Tongxinluo（liquid to free the network vessels of the heart）group

with 10in each.Naoluo Xintong group and Tongxinluo group was given 0.93g/ml of Naoluo Xintong Liquid and 0.03g/ml of Tongxinluo Liquid respectively

1ml/（100g.d）of intragastric administration for 14consecutive days.The model group and normal group were given same amount of normal saline.Fibrin degradation product（FDP）

D-dimer（DD）

prothrombin time（PT）

thrombin time（TT）

activated partial thromboplastin time（APTT）and plasma fibrinogen（Fbg） was detected and the neurological deficit was scored after 14days of administration.Results Comparing with the model group

the neurological deficit was significantly relieved in Naoluo Xintong group and Tongxinluo group after 14days of treatment（P<0.01）.There was significant difference in the neurological deficit between Naoluo Xintong group and Tongxinluo group after 14days of treatment（P<0.05）.Comparing with the normal group

PT

APTT and TT was significantly shortened and Fbg

FDP and D-D was significantly increased in the model group

PT was significantly shortened and FDP was significantly increased in Naoluo Xintong group and Tongxinluo group

and D-D was significantly increased in Naoluo Xintong group（P<0.05or P<0.01）.Comparing with the model group

there were significant differences in the indexes of coagulation and fibrinolytic system in Naoluo Xintong group and Tongxinluo group（P< 0.05or P<0.01）.Conclusion Naoluo Xintong could extend PT

APTT and TT and decrease the levels of FDP

D-D and Fbg

which may be relevant to its neuroprotective effect in treating ischemic cerebrovascular disease.