Objective To observe the therapeutic effect and its influencing factors of network vessel-freeing formula as a topical wash for chemotherapy-induced peripheral neuropathy （C IPN） .Methods Sixty eight cases of CIPN were randomized into the treatment group and control group

with 34cases in each.The treatment group was given network vessel-freeing formula as a topical wash

60min each time once daily.The control group was treated with intramuscular injection of cobamamide

1mg each time

once daily.The grading scores of peripheral neurotoxicity were observed and compared in both groups before and after 14-day treatment according to CIPN questionnaire.Results There were 7cases excellent

14cases valid and 13cases invalid in the treatment group

with a total effective rate of 61.76%.There were 4cases excellent

9cases valid and 21cases invalid in the control group

with a total effective rate of 38.24%.There was no significant difference between groups in the total effective rate （ P>0.05 ） .There were 5cases excellent

12cases valid and 4cases invalid among 21cases of CIPN induced by oxaliplatin in the treatment group

with a total effective rate of 80.95%.There were 2cases excellent

4cases valid and 7cases invalid among 13cases of CIPN induced by paclitaxel in the treatment group

with a total effective rate of 30.77%.There was no significant difference between different chemotherapy drugs in the treatment group （ P>0.05 ） .There were 5cases valid and 2cases invalid among 7cases of peripheral neuropathy （ grade 1 ）

with a total effective rate of 71.34%in the treatment group. There were 12cases valid and 7cases invalid among 19cases of peripheral neuropathy （ grade 2 ）

with a total effective rate of 63.16%in the treatment group.There were 4cases valid and 4cases invalid among 8cases of peripheral neuropathy （ grade 3）

with a total effective rate of 50.00%in the treatment group.The pairwise comparisons showed no significant difference （ P>0.05 ） .There was no treatment-related adverse reaction.Conclusion The therapeutic effect of network vessel-freeing formula for CIPN is as same as that of cobamamide

with a better effect on CIPN induced by oxaliplatin.