Objective To observe the therapeutic effect and mechanism of Shengji Yuhong Paste（Flesh-Engendering Jade and Red Paste）for chronic leg ulcers.Methods Totally 257 cases of chronic leg ulcers were randomized into test group of 127 cases and control group of 130 cases.The test group was externally applied with gauze of Shengji Yuhong Paste and the control group with Vaseline gauze every other day.One treatment course lasted for 4 weeks.The reducing rates of wound area

wound healing time

granulation growth

level of hydroxyproline and hemoglobin were observed on the 3rd

7th

14th

21st and 28th day of treatment

and the general efficacy was evaluated after treatment.Results The total effective rate of the test group and the control group was 99.21% and 70.77% respectively

with significant dfference between groups（P<0.01）.The reducing rate of wound area in the test group was significantly higher than that in the control group on the 3rd

7th

14th

21st and 28th day of treatment（P<0.01）.There was no significant difference between groups in the wound healing time（P>0.05）.The scores of ulcer depth

granulation color and covering area were significantly decreased in the test group on the 7th

14th

21st and 28th day of treatment（P<0.05）.Comparing with the control group

the scores of ulcer depth were significantly decreased in the test group on the 14th

21st and 28th day of treatment（P<0.05）

the scores of granulation color were significantly decreased on the 7th

14th

21st and 28th day of treatment（P<0.05）

and the scores of covering area were significantly decreased on the 21st and 28th day of treatment（P<0.05）.The content of hydroxyproline and hemoglobin was significantly increased in both groups after treatment（P<0.01）

especially in the test group（P<0.01）. Conclusion Shengji Yuhong Paste is effective and safe for chronic leg ulcers.It can improve the healing rate of chronic leg ulcers by increasing the content of hydroxyproline and hemoglobin and promote the growth of granulation.