Objective To observe the therapeutic effect of kidney-supplementing liver-coursing therapy for Parkinson’s disease（PD） complicated by mild to moderate depression with liver-kidney yin deficiency syndrome.Methods Sixty PD patients were randomized into the treatment group and control group

with 30 in each.Both groups were given sertraline hydrochloride and levodopa according to the international medication guiding principle for PD.The treatment group was added with kidney-supplementing liver-coursing formula.The treatment course lasted for 12 months.The Unified Parkinson’s Disease Rating Scale（UPDRS） and Hamilton Depression Rating Scale（HAMD） were used to evaluate the therapeutic effect before and after treatment.The average dosages of sertraline hydrochloride and levodopa were observed in both groups before and after treatment.Results The total score of UPDRS was decreased in the treatment group after treatment

but comparison within group showed no significant difference（P>0.05）.The total score of UPDRS was increased in the control group after treatment

but comparison within group showed no significant difference（P>0.05）.The total score of UPDRS in the treatment group was lower than that in the control group after treatment（P<0.05）.The total score of HAMD was significantly decreased in the treatment group after treatment（P<0.01）.The total score of HAMD was decreased in the control group after treatment

but comparison within group showed no significant difference（P>0.05）.The total score of HAMD in the treatment group was lower than that in the control group after treatment（P<0.01）.There were 11 cases without depression

15 cases of mild depression and 4 cases of moderate depression in the treatment group after treatment.There were 3 cases without depression

16 cases of mild depression and 11 cases of moderate depression in the control group after treatment.There were significant differences between groups in the cases of mild and moderate depression after treatment（P<0.05）.Comparing within the control group

there was no significant difference in each factor score of HAMD（P>0.05）.All factor scores of HAMD were significantly deceased in the treatment group after treatment（P<0.05 or P<0.01）.All factor scores of HAMD in the treatment group were significantly lower than those in the control group after treatment（P<0.05 or P<0.01）.Conclusion Kidney-supplementing liver-coursing therapy can relieve the motor symptoms and depression of PD patients with liver-kidney yin deficiency syndrome and reduce the daily dosage of sertraline hydrochloride and levodopa.