Objective To research the effect and mechanism of Refined Dahuang Zhechong Pill [Refined Rhubarb（Radix et Rhizoma Rhei） and Ground Beetle（Eupolyphaga seu Steleophaga） Pill

RDZP] on arterial thrombosis and observe the influence of titanium-aluminum intermetallic compound porous material on drug action.Methods Fifty SD rats were randomized into the normal group

model group

DZP group

RDZP group and porous material group

with 10 in each.The arterial thrombosis models were induced by ferric chloride in all groups except normal group.DZP

RDZP and RDZP processed by titanium-aluminum intermetallic compound porous material were given to the DZP group

RDZP group and porous material group respectively.Each administration group was given 1ml/100g of corresponding drug solution intragastrically based on body weight twice daily for one week.The normal group and model group were given the same volume of saline intragastrically.The pathological situation of carotid artery in rats was observed by microscope.The dry weight of thrombosis

platelet count

hemorheology

activated partial thromboplastin time（APTT）

prothrombin time（PT） blood coagulation and the content of thromboxane B2（TXB2） and 6-keto-prostaglandin F1α（6-Keto-PGF1α） were recorded.Results The thrombosis could be seen in all modeling groups and the dry weight of thrombosis in the model group was the heaviest.Comparing with the model group

the dry weights of thrombosis were significantly reduced in the DZP group

RDZP group and porous material group（P<0.05）

especially in the porous material group（P<0.05 or P<0.01）.Comparing with the normal group

the platelet count and TXB2 content were significantly increased and 6-keto-PGF1α content were significantly decreased in the model group（P<0.05）.Comparing with the model group

the platelet count and TXB2 content were significantly decreased and 6-keto-PGF1α content were significantly increased in the DZP group

RDZP group and porous material group（P<0.05）.Comparing with the DZP group and RDZP group

the platelet count and TXB2 content were significantly decreased in the porous material group（P<0.05 or P<0.01）.Comparing with the normal group

the blood viscosity was significantly increased but APTTand PT were significantly shortened in the model group（P<0.05）.Comparing with the model group

the blood viscosity was significantly decreased but APTTand PT were significantly prolonged in the DZP group

RDZP group and porous material group（P<0.05）.Conclusion RDZP can obviously inhibit arterial thrombosis

improve blood rheology and prolong APTTand PT that may be relevant to increasing 6-keto-PGF1α content and decreasing TXB2 content.Titanium-aluminum intermetallic compound porous material can be applied in the separation and filtering of Chinese medicinal to improve efficacy.