Objective To observe the therapeutic effect of self-made Jiedu Xifeng Decoction（Toxin-Resolving Wind-Extinguishing Decoction） combined with western medicine for severe hand-foot-mouth disease（HFMD）.Methods Totally 194 cases of HFMD were randomized into the treatment group（97 cases） and control group（97 cases）.Both groups were given conventional symptomatic treatment such as the administration of ribavirin

corticosteroids

gamma globulin and mannitol.Jiedu Xifeng Decoction was added in the treatment group.The therapeutic effect

fever time

subsided time of rash and herpes

duration of easily frightened and trembling

hospital stay and hospitalization costs were observed.Results There were 86 cases（88.65%） cured

9 cases improved（9.28%） and 2 cases died（2.07%） in the treatment group.There were 84 cases（86.60%） cured

8 cases improved（8.25%） and 5 cases died（5.15%） in the control group.There was no significant difference between groups in the cure rate and mortality（P>0.05）.The duration of easily frightened and trembling in the treatment group was shorter than that in the control group（P<0.05）.The hospitalization cost in the treatment group was less than that in the control group（P<0.05）.Conclusion Jiedu Xifeng Decoction can obviously alleviate easily frightened and trembling and reduce hospitalization costs.