抗纤灵方治疗慢性肾脏病3期患者110例临床研究

张长明; 周家俊; 何立群; 吴同茹; 彭文; 王云满; 王浩; 张先闻; 邓跃毅; 王怡

doi:10.13288/j.11-2166/r.2013.03.012

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抗纤灵方治疗慢性肾脏病3期患者110例临床研究

临床研究 | 更新时间：2021-11-17

- 抗纤灵方治疗慢性肾脏病3期患者110例临床研究
- Clinical Observation on Kangxianling Formula for 110 Cases of Chronic Kidney Disease of StageⅢ
- 中医杂志 2013年54卷第3期页码：214-217
- 作者机构：
  
  1. 上海中医药大学附属市中医医院
  2. 上海中医药大学附属曙光医院
  3. 上海中医药大学附属普陀医院
  4. 上海中医药大学附属龙华医院
  5. 上海中医药大学附属岳阳医院
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目（81173219）;科技部中医药行业科研专项（201007005）;高等学校博士学科点专项科研基金资助项目（20093107110006）;上海市科委创新行动计划项目（11DZ1973100）;上海高校创新团队建设项目
- DOI：10.13288/j.11-2166/r.2013.03.012
  中图分类号： R277.5
- 纸质出版：2013
- 稿件说明：
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[1]张长明,周家俊,何立群,吴同茹,彭文,王云满,王浩,张先闻,邓跃毅,王怡.抗纤灵方治疗慢性肾脏病3期患者110例临床研究[J].中医杂志,2013,54(03):214-217.

ZHANG Changming1, ZHOU Jiajun1, HE Liqun2, et al. Clinical Observation on Kangxianling Formula for 110 Cases of Chronic Kidney Disease of StageⅢ[J]. Journal of Traditional Chinese Medicine2013, 54(3): 214-217.
[1]张长明,周家俊,何立群,吴同茹,彭文,王云满,王浩,张先闻,邓跃毅,王怡.抗纤灵方治疗慢性肾脏病3期患者110例临床研究[J].中医杂志,2013,54(03):214-217. DOI： 10.13288/j.11-2166/r.2013.03.012.

ZHANG Changming1, ZHOU Jiajun1, HE Liqun2, et al. Clinical Observation on Kangxianling Formula for 110 Cases of Chronic Kidney Disease of StageⅢ[J]. Journal of Traditional Chinese Medicine2013, 54(3): 214-217. DOI： 10.13288/j.11-2166/r.2013.03.012.

摘要

目的观察抗纤灵方对慢性肾脏病（CKD）3期患者的临床疗效。方法 215例CKD患者随机分成治疗组和对照组。其中治疗组110例

对照组105例。两组患者入院后均予基础治疗。治疗组加服抗纤灵方

每日2次。对照组加服氯沙坦50～100mg

晨顿服。两组疗程均为16周。治疗前后进行临床症状评分并测定肾功能、血脂及尿蛋白定量水平。观察综合疗效和不良反应。结果治疗组治疗后腰酸、乏力、纳呆、浮肿、肌肤甲错评分及总积分明显下降（P<0.05）。对照组治疗后腰酸、乏力、肌肤甲错评分较治疗前下降（P<0.05）。治疗组腰酸、乏力、纳呆、肌肤甲错评分及总积分下降明显优于对照组（P<0.05）。治疗组总有效率为77.3%

对照组为51.4%

治疗组疗效优于对照组（P<0.05）。治疗组治疗后肾功能、血脂及尿蛋白定量显著改善并且优于对照组（P<0.05）。结论抗纤灵方对CKD3期患者有良好的临床疗效和较好的安全性。

Abstract

Objective To observe the therapeutic effect of Kangxianling Formula（formula for renal fibrosis）for chronic kidney disease（CKD）of stageⅢ.Methods Totally 247CKD patients were randomized into treatment group and control group

with 129cases and 118cases in each.There were 19shedding cases and 110complete cases in the treatment group.There were 13shedding cases and 105complete cases in the treatment group.Both groups were given basic treatment.The treatment group was given Kangxianling Formula

twice daily.The control group was given 50-100mg losartan in the morning.The treatment course lasted for 16weeks.The symptoms

blood urea nitrogen（BUN）

serum creatinine（SCr）

glomerular filtration rate（GFR）

triglyceride（TG）

total cholesterol（TC）and 24-hour urinary protein（24hUP）were detected.The therapeutic effect and side effect were observed.Results Backache

fatigue

poor appetite

edema and squamous dry skin were significantly relieved and the total scores were significantly decreased in the treatment group（P<0.05）.Backache

fatigue and squamous dry skin were significantly relieved in the control group（P<0.05）.Comparing with the control group

backache

fatigue

poor appetite and squamous dry skin were significantly relieved and the total scores were significantly decreased in the treatment group（P<0.05）.The total effective rate of the treatment group and the control group was 77.3%and 51.4%respectively

the treatment group was superior to the control group（P<0.05）.After treatment

the levels of BUN

SCr

TC and 24hUP were significantly decreased（P<0.05）

but GFR was significantly increased（P<0.05）in the treatment group.There was no significant difference in each index between before and after treatment in the control group（P>0.05）.After treatment

the levels of BUN

SCr

TC and 24hUP in the treatment group were significantly lower than those in the control group（P<0.05）

but GFR in the treatment group was significantly higher than that in the control group（P<0.05）.Conlcusion Kangxianling Formula is effective and safe for CKD of stageⅢ.

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