Objective To compare the differences in urine N-Acetyl-beta-D-glucosaminidase（NAG） and serum Cyst-c in primary hypertensive patients with different TCM syndromes.Methods Totally 240 cases of primary hypertension were randomized into the phlegm-stasis obstructing the network vessels group（78 cases）

yin deficiency with yang hyperactivity group（84 cases） and kidney deficiency group（78 cases）.The urine NAG and serum Cyst-c were detected and compared.Results The phlegm-stasis obstructing the network vessels syndrome accounted for 32.5%

yin deficiency with yang hyperactivity syndrome accounted for 35.0% and kidney deficiency syndrome accounted for 32.5% in 240 patients

but with no significant difference between syndromes（P>0.05）.The urine NAG in the phlegm-stasis obstructing the network vessels group was significantly lower than that in the kidney deficiency group（P<0.05）.The serum Cyst-c was gradually increased in the phlegm-stasis obstructing the network vessels group

yin deficiency with yang hyperactivity group and kidney deficiency group

and the pairwise comparison showed a significant difference between groups（P<0.01）.Conclusion Comparing with primary hypertensive patients with phlegm-stasis obstructing the network vessels syndrome and yin deficiency with yang hyperactivity syndrome

the levels of urine NAG and serum Cyst-c in primary hypertensive patients with kidney deficiency syndrome are higher and the early kidney damage is more severe.