To review the theory and application of the "syndrome and treatment pharmacokinetics" pharmaceutical innovation in the past twenty years

which is a holism-guided reductionism research. "syndrome and treatment pharmacokinetics" can examine the absorbed bioactive compound （ABC） of TCM prescription in vivo through the qualitative and quantitative analysis. Bioethnopharmaceutical analytical pharmacology （BAP） is an idea for elucidating ABC in traditional Chinese medicine （TCM） formula or herbal remedy. ABC is focused on as a hub of pharmacy strategy in the subsequent research

including ethnopharmacokinetic-and activity-guided isolation （EAGI）

as well as researches on ABC to infer the mechanism of depression comorbidity related to liver-qi stagnation. The in-depth study of ABC and its mechanism is help for opening up a new approach to research drug R&D and pathogenesis.In addition

our work can melts the TCM "components and combinations" together and assist each other in scientific research.