Objective To observe the mechanism of Huazhuo Jiedu Formula （turbidity-transforming toxin-resolving formula

HJF） for lipid disorders with insulin resistance （IR）.Methods Among 30 SD rats

10 rats were selected as the blank control group and other rats were modeled with low-dose streptozotocin （STZ） and high fat diet. Sixteen successfully modeling rats were randomized into model group and HJF group

with 8 in each. The HJF group was given 3g crude drug/（kg·d） of HJF granules. Normal saline was given to the blank control group and model group. The intragastric administration lasted for 8 weeks. Fasting blood glucose （FBG）

fasting serum insulin （FINS）

triglyceride （TG）

total cholesterol （TC） and free fatty acid （FFA） were detected 8 weeks later. The expression of diacylglycerol acyltransferase 2 （DGAT2） mRNA was examined by real time polymerase chain reaction （RT-PCR）.Results Comparing with the blank control group

FBG

FINS

TG

TC and FFA were significantly increased in the model group （P<0.01）. Comparing with the model group

FBG

FINS

TG

TC and FFA were significantly decreased in the HJF group （P<0.01 or P<0.05）. Comparing with the model group

DGAT2 mRNA expression was significantly decreased in the HJF group （P<0.01）.Conclusion HJF can inhibit DGAT2mRNA expression in liver tissue of lipid disorders rats with IR

which may be part mechanism for ameliorating IR and lipid disorders.