Objective To research the common metabolomic feature of rheumatism with damp-heat syndrome.Methods A metabolomic study of serum samples was conducted in 30ankylosing spondylitis（AS）patients with damp-heat syndrome

29 gouty arthritis（GA）patients with damp-heat syndrome and 44healthy volunteers by gas chromatography-time-of-flight mass spectrometry（GC-TOFMS）.The Common difference metabolomics associated with damp-heat syndrome in AS patients with damp-heat syndrome and GA patients with damp-heat syndrome were compared with the healthy volunteers.Results Comparing with the healthy volunteers

α-hydroxy acid

phosphoric acid and mannose was significantly increased but ethanolamine was significantly decreased in AS patients with damp-heat syndrome and GA patients with damp-heat syndrome.Conclusion The common metabolomic feature of rheumatism with damp-heat syndrome may beα-hydroxy acid

phosphoric acid

mannose and ethanolamine.