Objective To study the Chinese medication law of chronic hepatitis B with damp-heat syndrome.Methods Totally 592 effective cases of chronic hepatitis B with damp-heat syndrome were selected and the formulas were extracted.The medication law was analyzed with frequency analysis

formula match

factor analysis and complex network.Results The top 5 frequently used medicinals for chronic hepatitis B with damp-heat syndrome were Fuling （Poria）

Baizhu （Rhizoma Atractylodis Macrocephalae）

Yexiazhu （Phyllanthi Urinariae Herba）

Zhuling （Polyporus） and Zexie （Rhizoma Alismatis）.There were 208 formulas with less than or equal to 3 remained medicinals after formula match.The formulas which frequency over 3 were:Yinchen Wuling Powder （76）

Sijunzi Decoction-Sini Powder-Wendan Decoction （41）

Longdan Xiegan Decoction （36）

Jiawei Xiaoyao Powder （7）

Chaihu Shugan Powder （5）

Yinchenhao Decoction （5）

Shenling Baizhu Powder （4）

Ganlu Xiaodu Elixir （3） and Wuwei Xiaodu Beverage-Yinchenhao Decoction （3）.There were 384 formulas with more than 3 remained medicinals after formula match and most were self-formulated.The characteristic root over 1 was selected as the standard of common factor.A Total of 43 common factors and the medicinal combinations corresponding to the common factors （occurrence frequency≥5） were obtained.The power function index value of edge weight distribution in the network graph of formulas was 1.8.Taking 1.8 as the value of α and 3 as the number of layers

a 3-layer network diagram was got by multilayer core network analysis.Conclusion The commonly used medicinals for chronic hepatitis B with damp-heat syndrome are dampness-dispelling medicinal

liver-coursing medicinal

toxin-resolving medicinal and blood-quickening medicinal.The top 3 frequently used formulas for chronic hepatitis B with damp-heat syndrome are Yinchen Wuling Powder

Sijunzi Decoction-Sini Powder-Wendan Decoction and Longdan Xiegan Decoction.The combinations of commonly used self-formulated formulas are dampness-dispelling+liver-coursing+toxin-resolving and qi-supplementing+blood quickening+dampness-dispelling

often with hepatoprotective and anti-transaminase medicinals according to modern pharmacology.