Objective To study the mechanism of Naoluo Xintong Liquid （liquid to free the network vessels of the brain and the heart） for rats with cerebral ischemia-reperfusion injury.Methods Forty Wistar rats were randomized into the normal group

model group

Naoluo Xintong group and Tongxinluo （liquid to free the network vessels of the heart） group

with 10 in each.The middle cerebral artery occlusion rat models were established with suture method and the thread embolism was pulled out a little （about 5 mm） to make ischemia-reperfusion injury 2 hours later.The Naoluo Xintong group and Tongxinluo group was given 1 ml/（100 g·d） of Naoluo Xintong Liquid （concentration=85.8 mg/ml） and Tongxinluo Liquid （concentration=30 mg/ml） respectively.The model group and normal group were given same amount of normal saline.The administration lasted for 14 consecutive days.The Morris water maze test was used to detect the escape latencies （EL） at different time points and the numbers of passing the location of the original platform within 120 seconds （Visits）.The regional cerebral blood flow （rCBF） was monitored during the modeling

5 minutes after the thread plugged in

reperfusion after 2 hours of ischemia

7 days after modeling and 14 days after modeling respectively.Results Comparing with the normal group

the ELs at different time points were significantly prolonged but the Visits were significantly reduced in the model group and Tongxinluo group （P<0.01）.Comparing with the model group and Tongxinluo group

the ELs at different time points were significantly shortened but the Visits were significantly increased in the Naoluo Xintong group （P<0.01）.Comparing with the normal group

the rCBF at different time points was significantly decreased in other groups （P<0.01）.Comparing with the model group

the rCBF was restored in the Naoluo Xintong group and Luoxintong group on the 7th and 14th day after modeling （P<0.01）.Conclusion Naoluo Xintong can improve learning and memory capacity by increasing rCBF

which play a protective effect on cerebral ischemia-reperfusion injury.