Objective To observe the therapeutic effect of acupuncture point regulatory-control（APRC）combined with lowdose clomipramine for obsessive-compulsive disorders（OCD）.Methods Totally 160OCD patients were randomized into the study group and control group

with 81and 79in each.Both groups were given the double-blind treatment after 2-week washout period.The study group was given 30min APRC and behavioral therapy once daily

5times weekly and given clomipramine（12.5mg/tablet）orally.The control group was given clomipramine（25mg/tablet）orally and analog APRC.The medication method in both groups was:1tablet daily since the 1st day

then 1tablet added every other day and increased to 6tablets on the 11th day.Finally

the dose of clomipramine was 75mg/d in the study group and 150mg/d in the control group.Both groups were treated for 12weeks.The therapeutic effect and adverse reactions were evaluated with Yale-Brown ObsessiveCompulsive Scale（Y-BOCS）

Hamilton Depression Scale（HAMD）

Brief Psychiatric Rating Scale（BPRS）and Treatment Emergent Symptom Scale（TESS）.Results The cure rate in the study group and control group was 48.15% and 30.38% respectively

with a significant difference between groups（P<0.05）.The total effective rate of the study group and the control group was 95.10% and 87.30% respectively

with significant difference between groups（P<0.05）.There were significant differences in the Y-BOCS scores between before and after treatment in both groups in the 2nd

4th

6th

8th and 12th week of treatment（P<0.05or P<0.01）

especially in the study group in the 4th

6th

8th and 12th week of treatment（P<0.05or P<0.01）.There were significant differences in the obsessions score and compulsions score of Y-BOCS

HAMD scores and BPRS scores between before and after treatment in both groups after 12weeks of treatment（P<0.01）

especially in the obsessions score and compulsions score of Y-BOCS and HAMD scores in the study group（P<0.05）.Conclusion Comparing with clomipramine used singly

the combo therapy of APRC and low-dose clomipramine is more effective for OCD with fewer adverse reactions and good safety.