Objective To observe the therapeutic effect of moxibustion under the peer education on human immunodeficiency virus （HIV） infection. Methods One hundred HIV patients were randomized into test group and control group

with 50 in each. The test group was given moxibustion under the peer moxibustion education and the control group was given general health education. The treatment lasted for 3 months and the observation lasted for 1 year. The comprehensive efficacy

symptom score

sign score

Karnofsky Performance Score （KPS）

quality of life （QOL） and CD4+T cell count were observed before and after treatment. Results The total effective rate of the test group and control group was 96.00% and 64.00% respectively

with significant difference between （P<0.01）. The scores of fever

fatigue

poor appetite

diarrhea

spontaneous sweating

night sweating

total scores of symptoms and signs

physiology field

emotion field and social relation field

KPS

CD4+T cell count and total score were significantly improved in the test group （P<0.05 or P<0.01）. The total score

KPS and enviromental relation score was significantly improved in the control group （P<0.05）. Comparing with the control group

the scores of fever

fatigue

poor appetite

diarrhea

spontaneous sweating

night sweating

total scores of symptoms and signs

physiology field

emotion field and social relation field

KPS

CD4+T cell count and total score were significantly improved in the test group （P<0.05 or P<0.01）. Conclusion The moxibustion under the peer education is effective for HIV infection and it can obviously relieve the symptoms and signs and improve the QOL.