Objective To research the TCM pattern characteristics of chronic hepatitis B virus （HBV） infected patients in different immune status. Methods Totally 200 HBV infected patients were collected and grouped into the immune tolerance group

immune clearance group and immune dysfunction group. The clinical epidemiology survey was designed. The general condition of patients in each group was investigated. The liver function and HBV indicators were detected. The TCM patterns were analyzed by screening main symptoms

tongue and pulse. Results The top five TCM patterns in the immune tolerance group were liver depression and spleen deficiency

spleen qi deficiency

heart-liver depressed heat

liver-kidney yin deficiency and liver depression and qi stagnation. The top five TCM patterns in the immune clearance group were damp-heat brewing internally

liver depression and spleen deficiency

liver depression and qi stagnation

heart-liver depressed heat and qi-yin deficiency. The top five TCM patterns in the immune dysfunction group were liver-kidney yin deficiency

qi-yin deficiency

spleen qi deficiency

liver blood deficiency and liver depression and qi stagnation. Conclusion The chronic HBV infected patients in different immune status are involved with 11 TCM patterns

mainly liver depression and spleen deficiency in immune tolerance

damp-heat brewing internally in immune clearance and liver-kidney yin deficiency in immune dysfunction.