Objective To observe the effect of qi-supplementing blood-quickening medicinal combined with dual antiplatelet therapy on the platelet function and thrombosis in acute myocardial infarction （AMI） rats. Methods Twelve rats among 59 SD rats were randomly selected as the sham operation group and other rats were established AMI models by ligation of the left anterior descending coronary artery. Thirty six successfully modeling rats were randomized into the model group

dual antiplatelet therapy group and qi-supplementing blood-quickening medicinal combined with dual antiplatelet therapy group

with 12 in each. The dual antiplatelet therapy group was gavaged with 9 mg/（kg·d） aspirin and 6.75 mg/（kg·d） clopidogrel. The qi-supplementing blood-quickening medicinal combined with dual antiplatelet therapy group was gavaged with 162 mg/（kg·d） Xinyue Capsule and 400 mg/（kg·d） Compound Chuanxiong Capsule on the basis of the dual antiplatelet therapy group. The model group and sham operation group were gavaged with distilled water for 28 days. The thrombus formation time

length

wet weight and dry weight of thrombosis in vitro

coagulation

platelet aggregation rate （PAgT）

thromboxane B2 （TXB2） and 6-keto-prostaglandin F1α （6-keto-PGF1α） was detected. The cardiac ventricular area and cross-sectional area ratio was calculated. Results Comparing with the sham operation group

the thrombus formation time of carotid artery in vivo and activated partial thromboplastin time （APTT） were significantly shortened

the length

wet weight and dry weight of thrombosis in vitro

fibrinogen （FIB） content and cardiac ventricular area and cross-sectional area ratio were significantly increased and 6-keto-PGF1α was significantly decreased in the model group （P<0.05 or P<0.01）. Comparing with the model group

the thrombus formation time in vivo was significantly prolonged

the length

wet weight and dry weight of thrombosis in vitro

PAgT and cardiac ventricular area and cross-sectional area ratio were significantly decreased

6-keto-PGF1α was significantly increased and coagulation was significantly improved in the qi-supplementing blood-quickening medicinal combined with dual antiplatelet therapy group （P<0.05 or P<0.01）. Conclusion The combo therapy of qi-supplementing blood-quickening medicinal and dual antiplatelet can inhibit the thrombosis of carotid artery with no obviously increased risk of bleeding.