Objective To observe the therapeutic effect of Modified Liujunzi Decoction for functional dyspepsia with depression.Methods Eighty cases of functional dyspepsia with depression were randomized into the treatment group and control group

with 40 in each.The control group was given domperidone tablets 10 mg each time

3 times daily and St.John’s wort extract tablets 300 mg each time

3 times daily.The treatment group was added with Modified Liujunzi Decoction one dose daily.Both groups were treated for 30 days.The total efficacy and the degrees of depression were evaluated.The motilin （MOT） and gastrin （GAS） was detected and the gastric emptying test was conducted.Results The total effective rate of TCM patterns in the treatment group and control group was 95.0% and 87.5% respectively

with a significant difference between groups （P<0.05）.Comparing with the control group

the scores of Hamilton Depression Rating Scale

the levels of MOT and GAS and the results of gastric emptying test in the treatment group were significantly improved （P<0.05）.Conclusion Modified Liujunzi Decoction can obviously relieve the symptoms of functional dyspepsia patients with depression.It can increase the levels of MOT and GAS and gastric emptying rate.