Objective To research the metabolic differences between different patterns of coronary heart disease （CHD） by metabolomics method.Methods Ten CHD patients with phlegm obstructing the heart vessels pattern

qi-yin deficiency pattern and qi stagnation blood stasis pattern were collected respectively and 10 healthy persons were collected as the normal group.The fasting plasma samples of subjects were collected in the morning.The ultra-high performance liquid chromatography/quadrupole-time of flight tandem mass spectrometer was used to analyze the endogenous small molecule metabolites in plasma samples of CHD patients with different patterns and healthy persons.The precise molecular weight of potential biomarkers could be obtained from the mass spectrum.The potential biomarkers were identified to explore the potential metabolomics markers of CHD patients with different patterns.Results Comparing with the normal group

a disorder of phospholipid metabolism

fatty acid metabolism and amino acid metabolism occurred in the CHD group and led to platelet aggregation significantly.The contents of glucose

arachidonic acid and linoleic acid were significantly increased in the qi stagnation blood stasis pattern group.The contents of phenylalanine

glycine

homoserine

glucose and phosphocreatine were low in the qi-yin deficiency pattern group.The glucose content in the phlegm obstructing the heart vessels pattern group was higher than that in the qi stagnation blood stasis pattern group.Conclusion The metabolites such as glucose

arachidonic acid

linoleic acid

phenylalanine

glycine

homoserine and creatine phosphate are closely related to the energy metabolism

lipid metabolism

glucose metabolism and amino acid metabolism.It is expected to become the material basis for TCM pattern identification of CHD.