Objective To evaluate the efficacy of kidney-supplementing blood-quickening medicinal for senile osteoporosis and its intervention effect on interleukin-1β（IL-1β）

IL-6and insulin-like growth factor-1（IGF-1）and study on its possible mechanism.Methods Two hundred male patients with senile osteoporosis were randomized into the treatment group and control group

with 100in each.The treatment group was given kidney-supplementing blood-quickening capsule.The control group was given Alendronate Sodium Tablets.Both groups were also given Caltrate D.All the patients were treated for 1year and followed up for 6months.The pain integration was observed.The dual-energy X-ray absorptiometry was used to detect the bone mineral density（BMD）of lumbar spine（L2-4）and left hip.The serum procollagen type I N-terminal propeptide（PINP） andβ-I collagen C-terminal peptide（β-CTX）was detected by electrochemiluminescence immunoassay.The serum levels of IL-6

IL-1βand IGF-1 were detected by enzyme-linked immunosorbent assay.Adverse reactions were monitored in both groups.Results The pain integrations were significantly improved in both groups after 6-month and 1-year treatment and 6month follow-up（P<0.05or P<0.01）.The pain integrations in the treatment group were significantly lower than those in the control group after 1-year treatment and 6-month follow-up（P<0.05）.The BMD of lumbar spine（L2-4）and left hip was significantly increased in both groups after 1-year treatment（P<0.05）.The PINP andβ-CTX was significantly improved in the treatment group after 1-year treatment and 6-month follow-up（P<0.05or P<0.01）

with a significant difference between groups（P<0.05）.The levels of IL-6and IL-1βwere significantly decreased but IGF-1level was significantly increased in both groups after 1-year treatment（P<0.05or P<0.01）

especially IL-6and IGF-1in the treatment group（P<0.05）.Conclusion Kidney-supplementing blood-quickening medicinal can relieve bone pain of osteoporosis in the aging male

regulate the levels of IL-1β

IL-6and IGF-1

improve bone turnover and increase bone density without obvious adverse reaction.