Objective To study the therapeutic effect of Spleen-Warming

Network Vessels-Freeing and Orifices-Opening Formula（SNOF）for Alzheimer’s disease（AD）.Methods Eighty cases of AD were randomized into the observation group and control group

with 40in each.The observation group was given SNOF one dose daily for 8weeks.The control group was given 5mg donepezil hydrochloride tablets once daily at bedtime for 4weeks and then 10mg for 4weeks.The plasma homocysteine（Hcy）was detected

mini-mental state examination（MMSE）scores were calculated and clinical symptoms were observed before and after treatment.The efficacy was evaluated after treatment.Results The total effective rate of the observation group and control group was 87.50%and 77.50%respectively

with a significant difference between groups（P<0.05）.The MMSE scores and the concentrations of Hcy were significantly improved in both groups after treatment（P<0.05）

especially in the observation group（P<0.05）.Conclusion SNOF is effective for AD.It can relieve clinical symptoms and neurological deficit in AD patients with phlegm-turbidity obstructing orifices pattern by decreasing the concentration of Hcy and increasing the MMSE score obviously.