Objective To observe the therapeutic effect and mechanism of Xiaotan Sanjie Formula（formula to disperse phlegm and dissipate binds）combined with chemotherapy for advanced gastric cancer.Methods Totally 67cases of advanced gastric cancer were randomized into the treatment group of 32cases and control group of 35cases.Both groups were given DeFazio capsules orally and intravenous infusion of oxaliplatin.The treatment group was added with Xiaotan Sanjie Formula one dosage daily.A 21-day continuous treatment was one course and the treatment lasted for four courses in both groups.The serum N-glycan was observed before and after treatment.The therapeutic effect was evaluated after treatment.Results The total effective rate and tumor control rate was 59.38% and 84.38%in the treatment group and 45.71% and 80.00%in the control group respectively

with no significant difference between groups（P>0.05）.The Peak3

Peak6and Peak7values of serum N-glycan were significantly increased but the Peak5and Peak9values of serum N-glycan were significantly decreased in both groups（P<0.01or P<0.05）.The Peak1and Peak2values of serum N-glycan were significantly decreased in the treatment group（P<0.01）

with a significant difference between groups（P<0.01or P<0.05）.The Peak4value of serum N-glycan in the treatment group was significantly higher than that in the control group（P<0.05）.Conclusion Xiaotan Sanjie Formula combined with chemotherapy is effective for advanced gastric cancer and it can regulate the expression of serum N-glycan.