Objective To evaluate the tonic and therapeutic effect of Buzhong Yiqi Pills（Center-Supplementing Qi-Boosting Pills）with benefit-damage index and general score（BDI-GS）evaluation system. Methods Totally 32 ICR mice were randomized into the blank control group and 0.75%

1.5% and 2.25% Buzhong Yiqi Pills groups

with 8 in each.The blank control group was given ordinary corn flour.The Buzhong Yiqi Pills groups were given corn flour mixed with 0.75%

1.5% and 2.25% Buzhong Yiqi Pills.Each group was free feeding and drinking.The body weight was weighed on the 12th day and the tissues of heart

lung

thymus

spleen

pancreas

liver

kidneys

gonads

and femur were taken and weighed.The organ coefficient

BDI and GS were calculated.The blood biochemical parameters were detected.Results The body weights were decreased in each group

but the weight loss trend in the Buzhong Yiqi Pills groups was slower than that in the blank control group.The GS of organ tissues in the 0.75%

1.5% and 2.25% Buzhong Yiqi Pills groups was 10.23

11.15 and 11.57 respectively.The GS of organ coefficient in the 0.75%

1.5% or 2.25% Buzhong Yiqi Pills groups was 9.24

9.43 and 10.06 respectively.The BID of thymus and femur in the 2.25% Buzhong Yiqi Pills group were much higher than that in the blank control group

with a significant difference（P<0.05 or or P<0.01）.The total protein content in the 2.25% Buzhong Yiqi Pills group and the serum creatinine（Scr） level in the 0.75% Buzhong Yiqi Pills group was significantly increased as compared with the blank control group（P<0.05）.There was no significant difference between the Buzhong Yiqi Pills groups and blank control group in other blood biochemical parameters（P>0.05）.Conclusion Buzhong Yiqi Pills can fortify the spleen

supplement qi

and enhance immunity.It shows significant effective on improving osteoporosis.