Totally 156 cases of esophageal cancer treated by ZHOU Zhongying from August 2003 to July 2012 were collected to establish case database. The disease location factors and pathological factors were extracted and ana- lyzed with frequency and factor analysis. There were 18 pathogenesis factors extracted including 12 pathological factors and 6 disease location factors. The common pathological factors of repletion patterns were blood stasis

phlegm turbid- ity

qi depression and fire heat. The common pathological factors of deficiency patterns were yin deficiency and qi de- ficiency. The disease location was mainly related to stomach

spleen

liver and lung. The pathogenesis factors those frequencies greater than 10% were analyzed and 5 common factors were extracted. Factor 1 was damp

fire heat and liver. Factor 2 was qi deficiency and yin deficiency. Factor 3 was blood stasis and phlegm turbidity. Factor 4 was qi depression

stomach and liver. Factor 5 was lung and stomach. The result suggested that Prof. ZHOU Zhongying trea- ted esophageal cancer from repletion patterns and deficiency patterns. The main repletion patterns were phlegm turbid- ity and blood stasis. The main deficiency patterns were yin deficiency and qi deficiency. The main disease location was stomach and closely related to liver and spleen.