Objective To observe the effect of Buzhong Yiqi Decoction（ Center-Supplementing Qi-Boosting Decoction

补中益气汤） on incision healing in rats with spleen qi deficiency pattern.Methods Sixty SD rats were randomized into the normal group

model group and Buzhong Yiqi Decoction group

with 20 in each.The rat models of spleen qi deficiency pattern were established in the model group and Buzhong Yiqi Decoction group.A 4 cm incision paralleled to the spine was made on the back of rats in the each of groups on the 19th day of modeling.The Buzhong Yiqi Decoction group was gavaged with 7g / kg of Buzhong Yiqi Decoction daily after operation.The normal group and model group were gavaged with an equal volume of distilled water.Ten rats were sacrificed respectively on the 3rd day and 7th day after operation in each group.The muscle tissue on both sides of surgical incision was sampled and dyed with routine HE staining.The inflammation and granulation tissue formation was observed.The fibroblast cells were counted.Results The new granulation tissue with new blood vessels

macrophages and lymphocytes could be seen in the Buzhong Yiqi Decoction group 7 days after operation.Comparing with the normal group

the number of fibroblasts was significantly decreased in the model group 3 days and 7 days after operation（ P <0.01）.Comparing with the model group

the number of fibroblasts was significantly increased in the Buzhong Yiqi Decoction group 3 days and 7 days after operation（ P < 0.05 or P < 0.01）.Conclusion Buzhong Yiqi Decoction can promote incision healing by relieving inflammation and granulation tissue formation of muscle tissue.