Objective To observe the therapeutic effect of Guizhi Fuling Capsule [capsule of Guizhi（ Ramulus Cinnamomi

桂枝） and Fuling（ Poria

茯苓） ]for varicocele-induced infertility. Methods Totally 121 cases of varicocele-induced infertility were randomized into the treatment group and control group

with 60 and 61 in each. The treatment group was given Guizhi Fuling Capsule 3 times daily. The control group was given Aescuven forte twice daily. One treatment course lasted for 3 months. The therapeutic effect and semen quality was observed after treatment. The diameter of left spermatic vein was measured by color Doppler ultrasound before and after treatment. Results The cure rate in the treatment group and control group was 8. 33% and 8. 20% respectively

with no significant difference between groups（ P > 0. 05）. The markedly effective rate

effective rate and total effective rate in the treatment group was 51. 67%

26. 67% and 86. 67% respectively

which was superior to 47. 54%

22. 95% and 78. 69% in the control group（ P < 0. 05）. The semen volume

sperm concentration

sperm motility

progressive motility（ PR） and normal morphology rate was significantly increased in both groups after treatment（ P < 0. 05）

especially the sperm concentration and PR in the treatment group（ P < 0. 05）. The diameter of left spermatic vein was significantly narrowed after treatment in patients with 1 and 2 degree varicocele in both groups（ P < 0. 05）

especially in patients with 2 degree varicocele in the treatment group（ P < 0. 05）. The patients were followed up for 3 months after treatment and there were 5 patients（ 2 patients in the treatment group and 3 patients in the control group） whose sexual partners got pregnant. Conclusion Guizhi Fuling Capsule can improve the semen quality in patients with varicocele-induced infertility and narrow the diameter of spermatic vein in patients with 1 and 2 degree varicocele.