Objective To research the efficacy and prognosis of integrative therapy based on Fuzheng Jiedu Xiaoji Formula（ vital qi-supporting

toxin-resolving and accumulations-dispersing formula

FJXF） for primary liver cancer（PLC）. Methods Totally 68 cases of PLC were randomized into the integrative medicine group（comprehensive therapy + modified FJXF） and western medicine group（comprehensive therapy）

with 34 in each. The liver function

alpha-fetoprotein（AFP）

prothrombin activity

efficacy in solid tumors

Child-Pugh classification of severity of liver disease and cumulative survival rate were observed before and after treatment. Results The level of serum albumin（ALB） was significantly increased in the integrative medicine group after treatment（ P < 0. 05）. The ALB level in the integrative medicine group was significantly higher than that in the western medicine group after treatment（P < 0. 05）. The response rate i. e. 33. 33% and stable rate i. e. 87. 88% of solid tumor in the integrative medicine group were significantly higher than those i. e. 17. 24% and 62. 68% respectively in the western medicine group after treatment（P < 0. 05）. There was no significant difference between groups in Child-Pugh grades at each time point（P > 0. 05）. The survival rate in the integrative medicine group was 97. 1% higher than 85. 3% in the western medicine group

but the difference was not significant（P > 0. 05）. Conclusion Integrative therapy based on FJXF can control recurrence and progression of PLC and improve the survival rate.