慢性阻塞性肺疾病缓解期肺气虚证和肺阴虚证患者IL-1β、IL-8、TNF-α水平的变化

王明乐; 吴红丽

doi:10.13288/j.11-2166/r.2014.07.015

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慢性阻塞性肺疾病缓解期肺气虚证和肺阴虚证患者IL-1β、IL-8、TNF-α水平的变化

临床研究 | 更新时间：2021-11-17

- 慢性阻塞性肺疾病缓解期肺气虚证和肺阴虚证患者IL-1β、IL-8、TNF-α水平的变化
- The Levels of IL-1β,IL-8 and TNF-α in Chronic Obstructive Pulmonary Disease Patient With Lung-Qi Deficiency Pattern and Lung-Yin Deficiency Pattern During Remission Stage
- 中医杂志 2014年55卷第7期页码：591-593
- 作者机构：
  
  1. 河南科技大学第一附属医院
  2. 黑龙江省农垦总局九三分局中心医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2014.07.015
  中图分类号： R259
- 纸质出版：2014
- 稿件说明：
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[1]王明乐,吴红丽.慢性阻塞性肺疾病缓解期肺气虚证和肺阴虚证患者IL-1β、IL-8、TNF-α水平的变化[J].中医杂志,2014,55(07):591-593.

WANG Mingle, WU Hongli. The Levels of IL-1β,IL-8 and TNF-α in Chronic Obstructive Pulmonary Disease Patient With Lung-Qi Deficiency Pattern and Lung-Yin Deficiency Pattern During Remission Stage[J]. Journal of Traditional Chinese Medicine2014, 55(7): 591-593.
[1]王明乐,吴红丽.慢性阻塞性肺疾病缓解期肺气虚证和肺阴虚证患者IL-1β、IL-8、TNF-α水平的变化[J].中医杂志,2014,55(07):591-593. DOI： 10.13288/j.11-2166/r.2014.07.015.

WANG Mingle, WU Hongli. The Levels of IL-1β,IL-8 and TNF-α in Chronic Obstructive Pulmonary Disease Patient With Lung-Qi Deficiency Pattern and Lung-Yin Deficiency Pattern During Remission Stage[J]. Journal of Traditional Chinese Medicine2014, 55(7): 591-593. DOI： 10.13288/j.11-2166/r.2014.07.015.

摘要

目的探讨慢性阻塞性肺疾病（COPD）缓解期肺气虚证和肺阴虚证患者炎性细胞因子的变化。方法收集COPD缓解期肺气虚证和肺阴虚证患者各50例

另选健康者50例设为对照组

检测各组受试者血清白细胞介素-8（IL-8）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）的水平。结果肺气虚组、肺阴虚组患者血清IL-1β、IL-8、TNF-α水平明显高于对照组

差异有统计学意义（P<0.05）;肺阴虚组患者血清IL-1β、IL-8、TNF-α水平明显高于肺气虚组（P<0.05）。结论 COPD缓解期肺气虚证、肺阴虚证患者血清IL-1β、IL-8、TNF-α水平存在差异

可能导致免疫功能紊乱。

Abstract

Objective To research the changes of cytokines in chronic obstructive pulmonary disease（ COPD） patient with lung-qi deficiency pattern and lung-yin deficiency pattern during remission stage. Methods Fifty COPD patients with lung-qi deficiency pattern and fifty COPD patients with lung-yin deficiency pattern were collected. Fifty healthy persons were selected as the control group. The levels of interleukin-8（IL-8）

interleukin-1β（IL-1β） and tumor necrosis factor-α（TNF-α） were detected. Results The levels of IL-1β

IL-8 and TNF-α in both groups of COPD patients were significantly higher than those in the control group（ P < 0. 05）

especially in COPD patients with lung-yin deficiency pattern（P < 0. 05）. Conclusion There is difference between COPD patients with lung-qi deficiency pattern and COPD patients with lung-yin deficiency pattern

which might result in immune dysfunction.

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