Objective To study ZHAN Libin’ s medication rules in treating cancer by data mining technology. Methods Totally 132 patients with cancer who received treatment in ZHAN Libin Expert Outpatient Services in the Second Hospital of Dalian Medical University were collected. The clinical information database was established. The herbs and herb categories were analyzed by descriptive statistical analysis. ZHAN Libin’ s medication characteristics were analyzed by cluster analysis and Bayesian networks. Results There were 132 patients

664 visits and 210 herbs involved. The herbs with frequency higher than 50% were Huangqi（ Radix Astragali

黄芪）

Fuling（ Poria

茯苓）

Dangshen（ Radix Codonopsis

党参）

Baihuasheshecao（ Herba Hedyotis

白花蛇舌草）

Danggui（ Radix Angelicae Sinensis

当归）

Banbianlian（ Herba Lobeliae Chinensis

半边莲）

Chenpi（ Pericarpium Citri Reticulatae

陈 皮）

Zhigancao（ Radix et Rhizoma Glycyrrhizae Praeparata cum Melle

炙甘草）

Chaobaizhu（ Atractylodis Macrocephalae Rhizoma Frictum

炒白术）

Banzhilian（ Herba Scutellariae Barbatae

半枝莲） and Shancigu（ Pseudobulbus Cremastrae seu Pleiones

山慈菇）. The commonly used herbs were deficiency-supplementing herb

heat-clearing toxin-resolving herb

qi-regulating herb

digestive herb

water-disinhibiting damp-percolating herb and blood-quickening pain-relieving herb. There were five herb cluster groups such as group of Huangqi

Fuling

Dangshen

Baihuasheshecao

Danggui

Zhigancao

Chenpi

Chaobaizhu

Banbianlian and Banzhilian

group of Mudanpi（ Cortex Moutan

牡 丹皮）

Zhizi（ Fructus Gardeniae

栀子）

Yujin（ Radix Curcumae

郁金）

Moyao（ Myrrha

没药）

Chuanlianzi（ Fructus Toosendan

川楝子） and Shancigu

group of Baizhu（ Rhizoma Atractylodis Macrocephalae

白术）

Zhishi（ Fructus Aurantii Immaturus

枳实）

Shanyao（ Rhizoma Dioscoreae

山药）

Baibiandou（ Semen Lablab Album

白扁 豆）

Jiaoshanzha（ Crataegi Fructus Ustus

焦山楂）

Chaomaiya（ Hordei Fructus Germinatus Frictus

炒麦芽）

Chaoshenqu（ Massa Medicata Fermentata Fricta

炒神曲）

Jineijin（ Endothelium Corneum Gigeriae Galli

鸡内金）

Jiangbanxia（ Rhizome Pinelliae Praeparata

姜半夏） and Gancao（ Radix et Rhizoma Glycyrrhizae

甘草）

group of Longgu（ Os Draconis

龙骨） and Muli（ Concha Ostreae

牡蛎） and group of Ejiao（ Colla Corii Asini

阿胶）

Shudihuang（ Radix Rehmanniae Praeparata

熟地黄）

Chuanxiong（ Rhizoma Chuanxiong

川芎）

Shengdihuang（ Radix Rehmanniae Recens

生地黄）

Maidong（ Radix Ophiopogonis

麦冬） and Duzhong（ Cortex Eucommiae

杜仲）. Huangqi was chosen as a target and the herbs with frequency higher than 20% were analyzed by Bayesian networks to get the main formula combined with Huangqi

Dangshen

Fuling

Shudihuang

Maidong

Ejiao

Danggui

Chuanxiong

Zhishi

Chaobaizhu（ Baizhu）

Chaoshenqu

Baihuasheshecao

Banbianlian

Duzhong and Gancao. Conclusion ZHAN Libin often uses deficiency-supplementing herb

heat-clearing toxin-resolving herb

qi-regulating herb

digestive herb

blood-quickening stasis-transforming herb and sedative or tranquilizing herb to treat cancer

reflecting the idea of supporting body resistance and anticancer.