Objective To evaluate the therapeutic effect of Hexue Tongmai Granules（ granules to harmonize the blood and free the vessels） combined with western medicine for cardio-cerebral-vascular diseases with phlegm-stasis intermingling pattern and its relation with the age

gender and disease severity of patients. Methods Totally 383 cases of cardio-cerebral-vascular diseases with phlegm-stasis intermingling pattern were randomized into the treatment group and control group

with 191 and 192 in each. The treatment group was given Hexue Tongmai Granules and western medicine. The control group was given placebo and western medicine. The therapeutic effect was observed after 8-week treatment. The total score of TCM pattern

angina score and National Institutes of Health Stroke Scale（ NIHSS） score were observed and compared. Results The total effective rate of the treatment group and control group was 78. 01% and 55. 73% respectively

with a significant difference between groups（ P < 0. 05）. The scores of patients with different gender were significantly decreased in both groups（ P < 0. 01）. The scores of patients with different gender in the treatment group were lower than those in the control group

especially NIHSS score of male patients（ P < 0. 05） and all scores of female patients（ P < 0. 01）. The decrement of all scores in the treatment group was significantly higher than that in the control group（ P < 0. 05 or P < 0. 01）. The scores of patients of different ages were significantly decreased in both groups（ P < 0. 01）. The scores of elderly patients in the treatment group were significantly lower than those in the control group（ P < 0. 01）. The decrement of all scores in the treatment group was significantly higher than that in the control group（ P < 0. 05 or P < 0. 01）. The scores of patients with mild

moderate or severe disease were significantly decreased in both groups（ P < 0. 01）. The scores of patients with mild or moderate disease in the treatment group were significantly lower than those in the control group（ P < 0. 01）. Conclusion The combo therapy of Hexue Tongmai Granules and western medicine is effective for cardio-cerebral-vascular diseases with phlegm-stasis intermingling pattern. There is no gender and age difference in efficacy. But the efficacy in patients with mild or moderate disease is superior to that in patients with severe disease.