Objective To observe the efficacy of integrative medicine for knee synovitis.Methods Totally 160 cases of knee synovitis were randomized into the treatment group and control group

with 80 in each.The treatment group was given integrative medicine such as intra-articular injection of 5-fluorouracil（ 5-FU）

oral administration of Juanbi Decoction

hot compress therapy with rigidity-relieving blockage-dredging herbs and functional training.The control group was given routine treatment such as intra-articular injection of lidocaine and triamcinolone acetonide

and local ultrashort wave or electromagnetic therapy.The efficacy and the numbers of intra-articular injection were compared in both groups after 4-week treatment.Results The total effective rate was 97.50% and 77.50% in the treatment group and control group respectively.There was a significant difference between groups in the total efficacy（ P < 0.05）.Cases with intra-articular injection less than or equal to 4 times were 76 cases（ 95.00%） in the treatment group and 61 cases（ 76.25%） in the control group with a significant difference between groups（ P < 0.01）.Conclusion The efficacy of integrative medicine for knee synovitis is superior to that of the routine western medicine treatment.