Objective To evaluate the efficacy of integrative medicine clinical pathway for irritable bowel syndrome（ IBS）. Methods A cohort study was adopted. Totally 83 cases of IBS were randomized into the pathway group with 41 cases and non-pathway group with 42 cases. The integrative medicine clinical pathway was established in the pathway group according to the treatment guidelines. The non-pathway group was given routine treatment. The relief of clinical symptoms

average hospital stays and average hospital costs were observed in both groups. Results The scores of abdominal pain

abdominal distention

diarrhea and constipation were significantly decreased after treatment in both groups（ P < 0. 05 or P < 0. 01）

especially the score of abdominal distention in the pathway group（ P < 0. 05）. The average hospital stays in the pathway group and non-pathway group were（ 5. 88 ± 2. 38） days and（ 6. 83 ±2. 88） days respectively

with no significant difference between groups（ P > 0. 05）. The average hospital costs in the pathway group and non-pathway group were（ 5609. 32 ± 1863. 17） yuan and（ 6616. 33 ± 2440. 68） yuan respectively

with a significant difference between groups（ P < 0. 05）. Conclusion The integrative medicine clinical pathway for IBS can effectively relieve symptoms and reduce the average hospital costs.