Objective To study the effects of Bushen Shengsui Formula（ formula to supplement the kidney and engender marrow） on neuroendocrine function in cerebral ischemia and reperfusion rats with kidney essence insufficiency syndrome. Methods The kidney essence insufficiency models were established in male SD rats by fear and excessive sexual intercourse. The left focal cerebral ischemia and reperfusion rat models were established with improved middle cerebral artery occlusion method. Eight normal rats were chosen as the normal group. Twenty- four successful modeling rats were randomized into the model group

Naoluo Xintong group and Bushen Shengsui Formula group

with 8 in each. The Naoluo Xintong group and Bushen Shengsui Formula group was respectively gavaged with 8. 54g / kg and 10. 25g / kg corresponding drugs twice daily. The model group was gavaged with the same amount of normal saline. The intragastric administration lasted for 2 weeks. The levels of adrenocorticotropic hormone（ ACTH）

thyroid stimulating hormone（ TSH）

erythropoietin（ EPO）

serum calcium and phosphorus were detected. Results Comparing with the normal group

the levels of ACTH

TSH

EPO and serum calcium were significantly decreased（ P <0. 05 or P < 0. 01） but the level of serum phosphorus was significantly increased（ P < 0. 05） in the model group. Comparing with the model group

the levels of serum phosphorus were significantly decreased in both groups and the level of TSH was significantly increased in the Bushen Shengsui Formula group（ P < 0. 05）. Conclusion Bushen Shengsui Formula can increase TSH

reduce serum phosphorus and regulate the neuroendocrine function of cerebral ischemia reperfusion rats with kidney essence insufficiency syndrome.